The changes of tissues components of the anterior abdominal wall of rats after plasty of considerable ventral defect

The quantitative morphological estimation of changes in microcirculatory, connective tissue and muscle-aponeurotic components of the anterior abdominal wall of rats were made after the alloplasty of considerable ventral defect by the polypropylene monofilament net "Prolene". Histological s...

Full description

Bibliographic Details
Main Author: Malkov I.I.
Format: Article
Language:Russian
Published: Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy 2008-01-01
Series:Морфологія
Subjects:
Online Access:http://www.morphology.dp.ua/_pub/MORPHO-2008-02-03/08miirvd.pdf
Description
Summary:The quantitative morphological estimation of changes in microcirculatory, connective tissue and muscle-aponeurotic components of the anterior abdominal wall of rats were made after the alloplasty of considerable ventral defect by the polypropylene monofilament net "Prolene". Histological study was carried out in 3 days, 10 days, 1 month, 3 months and 1 year after implantation of polypropylene prosthetic device. 68 rats were distributed in 3 experimental groups: 1) the plasty by pull and approximation of wound edges with the layer by layer wound closure; 2) the plasty by the fixation of polypropylene monofilament net "Prolene" with the subsequent pull and approximation of defect edges; 3) the plasty by the fixation of net without the subsequent pull and approximation of defect edges. It was revealed that mechanical tension of muscle-aponeurotic layer of abdominal wall during the pull and approximation of experimental defect edges is a substantial factor which increases the terms of scarring, and also causes the permanent degenerative processes in muscle-aponeurotic structures. It is accompanied by the deficit of microcirculatory supplement of structures, the dystrophic changes in muscular fibres, hyperplasia of connective tissue components of muscle-aponeurotic layer of anterior abdominal wall with the most prominent pathological changes from 10th day to the end of 3th month after alloplasty. Application a polypropylene net for the plasty without mechanical tension of muscle-aponeurotic structures optimizes the recovery and adaptation processes during the first 3 months after operation.
ISSN:1997-9665