Physiology-Based Revascularization of Left Main Coronary Artery Disease

Physiology-Based Revascularization of Left Main Coronary Artery Disease

It is of critical importance to correctly assess the significance of a left main lesion. Underestimation of significance beholds the risk of inappropriate deferral of revascularization, whereas overestimation may trigger major but unnecessary interventions. This article addresses the invasive physio...

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Main Authors: Peter Kayaert, Mathieu Coeman, Sofie Gevaert, Michel De Pauw, Steven Haine
Format: Article
Language:English
Published: Hindawi-Wiley 2021-01-01
Series:Journal of Interventional Cardiology
Online Access:http://dx.doi.org/10.1155/2021/4218769
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spelling doaj-c8e261d7436c43a7907e79e4b4c9d59f2021-02-22T00:00:58ZengHindawi-WileyJournal of Interventional Cardiology1540-81832021-01-01202110.1155/2021/4218769Physiology-Based Revascularization of Left Main Coronary Artery DiseasePeter Kayaert0Mathieu Coeman1Sofie Gevaert2Michel De Pauw3Steven Haine4Department of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyDepartment of CardiologyIt is of critical importance to correctly assess the significance of a left main lesion. Underestimation of significance beholds the risk of inappropriate deferral of revascularization, whereas overestimation may trigger major but unnecessary interventions. This article addresses the invasive physiological assessment of left main disease and its role in deciding upon revascularization. It mainly focuses on the available evidence for fractional flow reserve and instantaneous wave-free ratio, their interpretation, and limitations. We also discuss alternative invasive physiological indices and imaging, as well as the link between physiology, ischemia, and prognosis.http://dx.doi.org/10.1155/2021/4218769
collection DOAJ
language English
format Article
sources DOAJ
author Peter Kayaert
Mathieu Coeman
Sofie Gevaert
Michel De Pauw
Steven Haine
spellingShingle Peter Kayaert
Mathieu Coeman
Sofie Gevaert
Michel De Pauw
Steven Haine
Physiology-Based Revascularization of Left Main Coronary Artery Disease
Journal of Interventional Cardiology
author_facet Peter Kayaert
Mathieu Coeman
Sofie Gevaert
Michel De Pauw
Steven Haine
author_sort Peter Kayaert
title Physiology-Based Revascularization of Left Main Coronary Artery Disease
title_short Physiology-Based Revascularization of Left Main Coronary Artery Disease
title_full Physiology-Based Revascularization of Left Main Coronary Artery Disease
title_fullStr Physiology-Based Revascularization of Left Main Coronary Artery Disease
title_full_unstemmed Physiology-Based Revascularization of Left Main Coronary Artery Disease
title_sort physiology-based revascularization of left main coronary artery disease
publisher Hindawi-Wiley
series Journal of Interventional Cardiology
issn 1540-8183
publishDate 2021-01-01
description It is of critical importance to correctly assess the significance of a left main lesion. Underestimation of significance beholds the risk of inappropriate deferral of revascularization, whereas overestimation may trigger major but unnecessary interventions. This article addresses the invasive physiological assessment of left main disease and its role in deciding upon revascularization. It mainly focuses on the available evidence for fractional flow reserve and instantaneous wave-free ratio, their interpretation, and limitations. We also discuss alternative invasive physiological indices and imaging, as well as the link between physiology, ischemia, and prognosis.
url http://dx.doi.org/10.1155/2021/4218769
work_keys_str_mv AT peterkayaert physiologybasedrevascularizationofleftmaincoronaryarterydisease
AT mathieucoeman physiologybasedrevascularizationofleftmaincoronaryarterydisease
AT sofiegevaert physiologybasedrevascularizationofleftmaincoronaryarterydisease
AT micheldepauw physiologybasedrevascularizationofleftmaincoronaryarterydisease
AT stevenhaine physiologybasedrevascularizationofleftmaincoronaryarterydisease
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