Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative...
Main Authors: | Kim Ohl, Klaus Tenbrock |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2021-04-01
|
Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.633845/full |
Similar Items
-
Comparing In-Vitro Effects of Two Immunosuppressive Drugs on the Expression of Foxp3 from Naïve CD4+ T Cells
by: Serineh Shajanian, et al.
Published: (2015-06-01) -
Cellular Metabolic Regulation in the Differentiation and Function of Regulatory T Cells
by: Ye Chen, et al.
Published: (2019-02-01) -
Inhibition of the PI3K-Akt-mTOR signaling pathway in T lymphocytes in patients with active tuberculosis
by: XueXuan Zhang, et al.
Published: (2017-06-01) -
Combinational therapy targeting the MET‐mTOR‐ROS loop disrupts mitochondrial autoregulatory machinery of liver cancer
by: Xing Huang, et al.
Published: (2020-12-01) -
Rapamycin Promotes ROS-Mediated Cell Death via Functional Inhibition of xCT Expression in Melanoma Under γ-Irradiation
by: Yunseo Woo, et al.
Published: (2021-04-01)