Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?
Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-04-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.633845/full |
| id |
doaj-c8dfde4b346342929e14aae1c4875685 |
|---|---|
| record_format |
Article |
| spelling |
doaj-c8dfde4b346342929e14aae1c48756852021-04-23T06:09:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-04-011210.3389/fimmu.2021.633845633845Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat?Kim OhlKlaus TenbrockOxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in the effect of NRF2 expression. This review focusses on the current understanding of oxidative stress in SLE T cells and its pathophysiologic and therapeutic implications.https://www.frontiersin.org/articles/10.3389/fimmu.2021.633845/fullKeap 1ROSmTORlupusTregsFoxp3 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Kim Ohl Klaus Tenbrock |
| spellingShingle |
Kim Ohl Klaus Tenbrock Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? Frontiers in Immunology Keap 1 ROS mTOR lupus Tregs Foxp3 |
| author_facet |
Kim Ohl Klaus Tenbrock |
| author_sort |
Kim Ohl |
| title |
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? |
| title_short |
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? |
| title_full |
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? |
| title_fullStr |
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? |
| title_full_unstemmed |
Oxidative Stress in SLE T Cells, Is NRF2 Really the Target to Treat? |
| title_sort |
oxidative stress in sle t cells, is nrf2 really the target to treat? |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2021-04-01 |
| description |
Oxidative stress is a major component of cellular damage in T cells from patients with systemic lupus erythematosus (SLE) resulting amongst others in the generation of pathogenic Th17 cells. The NRF2/Keap1 pathway is the most important antioxidant system protecting cells from damage due to oxidative stress. Activation of NRF2 therefore seems to represent a putative therapeutic target in SLE, which is nevertheless challenged by several findings suggesting tissue and cell specific differences in the effect of NRF2 expression. This review focusses on the current understanding of oxidative stress in SLE T cells and its pathophysiologic and therapeutic implications. |
| topic |
Keap 1 ROS mTOR lupus Tregs Foxp3 |
| url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.633845/full |
| work_keys_str_mv |
AT kimohl oxidativestressinsletcellsisnrf2reallythetargettotreat AT klaustenbrock oxidativestressinsletcellsisnrf2reallythetargettotreat |
| _version_ |
1721513596253372416 |