Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position

Direct Access to Substituted 4-CF3 β-Lactams at the C-3 Position

Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.

Bibliographic Details
Main Authors: Monika Skibińska, Marcin Kaźmierczak, Thierry Milcent, Tomasz Cytlak, Henryk Koroniak, Benoit Crousse
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Chemistry
Subjects:
lactams
fluorine
alkylation
deprotonation
functionalization
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00526/full
Description
Summary:Mono- and disubstituted 4-CF3 β-lactams at the C-3 position have been obtained stereoselectively under basic conditions. A wide range of function such as alcohols, alkyls, aryls, esters, and double and triple bonds have been introduced.
ISSN:2296-2646

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