Activation of Interleukin-1β Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes

Activation of Interleukin-1β Release by the Classical Swine Fever Virus Is Dependent on the NLRP3 Inflammasome, Which Affects Virus Growth in Monocytes

Classical swine fever virus (CSFV) is a classic Flavivirus that causes the acute, febrile, and highly contagious disease known as classical swine fever (CSF). Inflammasomes are molecular platforms that trigger the maturation of proinflammatory cytokines to engage innate immune defenses that are indu...

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Bibliographic Details
Main Authors: Shuangqi Fan, Jin Yuan, Shaofeng Deng, Yuming Chen, Baoming Xie, Keke Wu, Mengjiao Zhu, Hailuan Xu, Yunzhen Huang, Jiongfeng Yang, Yangyi Zhang, Jinding Chen, Mingqiu Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
classical swine fever virus
Flavivirus
NLRP3 inflammasome
interleukin-1β
monocyte
innate immune response
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00225/full

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