Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration

Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration

Abstract Background Potassium octatitanate fibers (K2O•8TiO2, POT fibers) are used as an asbestos substitute. Their physical characteristics suggest that respirable POT fibers are likely to be carcinogenic in the lung and pleura. However, previous 2-year inhalation studies reported that respired POT...

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Bibliographic Details
Main Authors: Mohamed Abdelgied, Ahmed M. El-Gazzar, William T. Alexander, Takamasa Numano, Masaaki Iigou, Aya Naiki-Ito, Hiroshi Takase, Akihiko Hirose, Yuhji Taquahashi, Jun Kanno, Mona Abdelhamid, Khaled Abbas Abdou, Satoru Takahashi, David B. Alexander, Hiroyuki Tsuda
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Particle and Fibre Toxicology
Subjects:
Potassium octatitanate fibers
MWCNT-7
Lung carcinoma
Malignant mesothelioma
Intra-tracheal intra-pulmonary spraying
TIPS
Online Access:http://link.springer.com/article/10.1186/s12989-019-0316-2

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