Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved

Effect of fibronectin, FGF-2, and BMP4 in the stemness maintenance of BMSCs and the metabolic and proteomic cues involved

Abstract Background Growing evidence suggests that the pluripotent state of mesenchymal stem cells (MSCs) relies on specific local microenvironmental cues such as adhesion molecules and growth factors. Fibronectin (FN), fibroblast growth factor 2 (FGF2), and bone morphogenetic protein 4 (BMP4) are t...

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Bibliographic Details
Main Authors: Lingling Chen, Morgan Carlton, Xiaodan Chen, Navdeep Kaur, Hollie Ryan, Tony J Parker, Zhengmei Lin, Yin Xiao, Yinghong Zhou
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells (MSCs)
Growth factor
Stemness maintenance
Metabolite
Proteome
Regenerative medicine
Online Access:https://doi.org/10.1186/s13287-021-02227-7

Internet

https://doi.org/10.1186/s13287-021-02227-7

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