Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA

Dual-Targeting Nanoparticle-Mediated Gene Therapy Strategy for Hepatocellular Carcinoma by Delivering Small Interfering RNA

As a gene therapy strategy, RNA interference (RNAi) offers tremendous tumor therapy potential. However, its therapeutic efficacy is restricted by its inferior ability for targeted delivery and cellular uptake of small interfering RNA (siRNA). This study sought to develop a dual-ligand nanoparticle (...

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Bibliographic Details
Main Authors: Qi Chang Zheng, Shuai Jiang, Yu Zhe Wu, Dan Shang, Yong Zhang, Shao Bo Hu, Xiang Cheng, Chen Zhang, Ping Sun, Yang Gao, Zi Fang Song, Min Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
small interfering RNA
gene therapy
targeted therapy
chitosan
hepatocellular carcinoma
drug delivery
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2020.00512/full

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