The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.

The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.

The cyclic GMP-AMP synthase (cGAS), upon cytosolic DNA stimulation, catalyzes the formation of the second messenger 2'3'-cGAMP, which then binds to stimulator of interferon genes (STING) and activates downstream signaling. It remains to be elucidated how the cGAS enzymatic activity is modu...

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Main Authors: Qiang Wang, Liyuan Huang, Ze Hong, Zhongshi Lv, Zhaomin Mao, Yijun Tang, Xiufang Kong, Senlin Li, Ye Cui, Heng Liu, Lele Zhang, Xiaojie Zhang, Lindi Jiang, Chen Wang, Qin Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5358892?pdf=render

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