Molecular Modeling, Synthesis and Biological Evaluation of <i>N</i>-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

Molecular Modeling, Synthesis and Biological Evaluation of <i>N</i>-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives of <i>N</i>-phenyl-4-hydroxy-6-methyl-2-quinolone-3-carboxamide were synthesized and characterized using...

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Bibliographic Details
Main Authors: Dima A. Sabbah, Shaima’ E. Hasan, Reema Abu Khalaf, Sanaa K. Bardaweel, Rima Hajjo, Khalid M. Alqaisi, Kamal A. Sweidan, Aya M. Al-Zuheiri
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
anticancer
colon cancer
PI3Kα
AKT
docking
quinolone-3-carboxamide
Online Access:https://www.mdpi.com/1420-3049/25/22/5348

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