Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4

Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARα-mediated redistribution of ABCB4

Fibrates, including bezafibrate (BF), upregulate the expression of ATP binding cassette protein B4 (ABCB4) through gene transcription in mice. To determine the effects of BF on the expression levels of ABCB4 and on the stimulation of biliary phosphatidylcholine (PC) transport in human HepG2 hepatobl...

Full description

Bibliographic Details
Main Authors: Junichi Shoda, Yoichi Inada, Atsutoshi Tsuji, Hiroshi Kusama, Tetsuya Ueda, Tadashi Ikegami, Hiroshi Suzuki, Yuichi Sugiyama, David E. Cohen, Naomi Tanaka
Format: Article
Language:English
Published: Elsevier 2004-10-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette protein B4
human hepatocyte
multidrug-resistance 3 P-glycoprotein
subcellular localization
functional activity
nuclear hormone receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520312542

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520312542

Similar Items