Double knockdown of α1,6-fucosyltransferase (<it>FUT8</it>) and GDP-mannose 4,6-dehydratase (<it>GMD</it>) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

Double knockdown of α1,6-fucosyltransferase (<it>FUT8</it>) and GDP-mannose 4,6-dehydratase (<it>GMD</it>) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

<p>Abstract</p> <p>Background</p> <p>Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans <it>...

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Bibliographic Details
Main Authors: Shitara Kenya, Iida Shigeru, Wakitani Masako, Inoue Miho, Mori Katsuhiro, Imai-Nishiya Harue, Satoh Mitsuo
Format: Article
Language:English
Published: BMC 2007-11-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/7/84

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