Association between apolipoprotein B gene polymorphisms and the risk of coronary heart disease (CHD): an update meta-analysis

• Main Authors: Jing-Zhan Zhang, Ying-Ying Zheng, Yi-Ning Yang, Xiao-Mei Li, Zhen-Yan Fu, Chuan-Fang Dai, Fen Liu, Bang-Dang Chen, Min-Tao Gai, Yi-Tong Ma, Xiang Xie
• Format: Article
• Language: English
• Published: Hindawi - SAGE Publishing 2015-12-01
• Series: Journal of the Renin-Angiotensin-Aldosterone System
• Online Access: https://doi.org/10.1177/1470320315615047

Objective: Polymorphisms in the apolipoprotein B ( apo B) gene have been reported to be associated with coronary heart disease (CHD). However, the results on this topic are conflicting. The present study aims to derive a more precise estimation of the relationship between CHD and apo B genetic polymorphisms by meta-analysis. Methods: We identified a total of 54 studies involving 7236, 10,912, and 14,102 individuals, respectively, for EcoRI, XbaI, and SpIns/Del polymorphisms by searching in PubMed, Web of Science, Google Scholar, the Cochrane Library, Wanfang Data, SinoMed, and CNKI. We utilized RevMan 5.0 software to perform the meta-analyses. Results: A significant statistical association between apo B EcoRI polymorphism and CHD was observed under an allelic ( p = 0.001, odds ratio (OR) = 1.33, 95% confidence interval (CI) = 1.12–1.57), dominant ( p = 0.005, OR = 1.22, 95% CI = 1.06–1.40), and recessive ( p = 0.04, OR = 1.33, 95% CI = 1.01–1.74) model. We also found similar association of apo B SpIns/Del polymorphism with CHD. However, we did not find association between apo B XbaI polymorphism and CHD. Conclusion: The current meta-analysis found an association of EcoRI polymorphism and SpIns/Del polymorphism with an increased risk of CHD. No significant association between apo B XbaI polymorphism and CHD we observed in the present study.