The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.

The ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.

The INhibitor of Growth (ING) proteins act as type II tumor suppressors and epigenetic regulators, being stoichiometric members of histone acetyltransferase and histone deacetylase complexes. Expression of the alternatively spliced ING1a tumor suppressor increases >10-fold during replicative sene...

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Bibliographic Details
Main Authors: Uma Karthika Rajarajacholan, Subhash Thalappilly, Karl Riabowol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3589274?pdf=render

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