Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice

Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease. Upon parasite uptake, macrophages, which are involv...

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Bibliographic Details
Main Authors: Federico Nicolás Penas, Davide Carta, Ganna Dmytrenko, Gerado A. Mirkin, Carlos Pablo Modenutti, Ágata Carolina Cevey, Maria Jimena Rada, Maria Grazia Ferlin, María Elena Sales, Nora Beatriz Goren
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
angiogenesis
new peroxisome proliferator-activated receptor gamma agonist
macrophages
inflammatory mediators
heart fibrosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01738/full

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