CTCF driven TERRA transcription facilitates completion of telomere DNA replication

CTCF driven TERRA transcription facilitates completion of telomere DNA replication

TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.

Bibliographic Details
Main Authors: Kate Beishline, Olga Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02212-w

Internet

https://doi.org/10.1038/s41467-017-02212-w

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