Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.

Bibliographic Details
Main Authors:	Qiaoli Ma, Benjamin V. Ineichen, Michael Detmar, Steven T. Proulx
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-01484-6

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spelling	doaj-c89920c210354bafbfed2555a5f8bed82021-05-11T07:46:21ZengNature Publishing GroupNature Communications2041-17232017-11-018111310.1038/s41467-017-01484-6Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged miceQiaoli Ma0Benjamin V. Ineichen1Michael Detmar2Steven T. Proulx3Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH ZurichBrain Research Institute, University of ZurichInstitute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH ZurichInstitute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH ZurichIt is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.https://doi.org/10.1038/s41467-017-01484-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx
spellingShingle	Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice Nature Communications
author_facet	Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx
author_sort	Qiaoli Ma
title	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_short	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_full	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_fullStr	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_full_unstemmed	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_sort	outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-11-01
description	It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.
url	https://doi.org/10.1038/s41467-017-01484-6
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Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

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