Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones

Ultrasound- and Molecular Sieves-Assisted Synthesis, Molecular Docking and Antifungal Evaluation of 5-(4-(Benzyloxy)-substituted phenyl)-3-((phenylamino)methyl)-1,3,4-oxadiazole-2(3H)-thiones

A novel series of 5-(4-(benzyloxy)substituted phenyl)-3-((phenyl amino)methyl)-1,3,4-oxadiazole-2(3H)-thione Mannich bases 6a–o were synthesized in good yield from the key compound 5-(4-(benzyloxy)phenyl)-1,3,4-oxadiazole-2(3H)-thione by aminomethylation with paraformaldehyde and substituted amines...

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Bibliographic Details
Main Authors: Urja D. Nimbalkar, Santosh G. Tupe, Julio A. Seijas Vazquez, Firoz A. Kalam Khan, Jaiprakash N. Sangshetti, Anna Pratima G. Nikalje
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
1,3,4-oxadiazoles
ultrasound
Mannich reaction
molecular sieves
antifungal activity
molecular docking
Online Access:http://www.mdpi.com/1420-3049/21/5/484

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http://www.mdpi.com/1420-3049/21/5/484

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