Structure of the cystic fibrosis transmembrane conductance regulator in the inward-facing conformation revealed by single particle electron microscopy

Structure of the cystic fibrosis transmembrane conductance regulator in the inward-facing conformation revealed by single particle electron microscopy

The most common inherited disease in European populations is cystic fibrosis. Mutations in the gene lead to loss of function of the cystic fibrosis transmembrane conductance regulator protein (CFTR). CFTR is a member of the ATP-binding cassette family of membrane proteins that mostly act as active t...

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Bibliographic Details
Main Authors: Ateeq Al-Zahrani, Natasha Cant, Vassilis Kargas, Tracy Rimington, Luba Aleksandrov, John R. Riordan, Robert C. Ford
Format: Article
Language:English
Published: AIMS Press 2015-05-01
Series:AIMS Biophysics
Subjects:
cystic fibrosis
CFTR
electron microscopy
ABCC7
Online Access:http://www.aimspress.com/biophysics/article/284/fulltext.html

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