Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior
Abstract Atherosclerosis usually occurs within the large arteries. It is characterized by the inflammation of the intima, which involves dynamic interactions between the plasma molecules; namely, LDL (low density lipoproteins), monocytes or macrophages, cellular components and the extracellular matr...
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doaj-c8819dc2c8124695875ceabbca8bd5862020-11-24T21:33:54ZengSpringerOpenAdvances in Difference Equations1687-18472017-07-012017111510.1186/s13662-017-1252-9Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behaviorWanwarat Anlamlert0Yongwimon Lenbury1Jonathan Bell2Department of Mathematics and Statistics, Faculty of Science and Technology, Thammasat UniversityCentre of Excellence in Mathematics, PERDO, CHEDepartment of Mathematics and Statistics, University of Mayland Baltimore CountyAbstract Atherosclerosis usually occurs within the large arteries. It is characterized by the inflammation of the intima, which involves dynamic interactions between the plasma molecules; namely, LDL (low density lipoproteins), monocytes or macrophages, cellular components and the extracellular matrix of the arterial wall. This process is referred to as plaque formation. If the accumulation of LDL cholesterol progresses unchecked, atherosclerotic plaques will form as a result of increased number of proliferating smooth muscle cells (SMCs) and extracellular lipid. This can thicken the artery wall and interfere further with blood flow. The growth of the plaques can become thrombotic and unstable, ending in rupture which gives rise to many life threatening illnesses, such as coronary heart disease, cardiovascular diseases, myocardial infarction, and stroke. A mathematical model of the essential chemical processes associated with atherosclerotic plaque development is analyzed, considering the concentrations of LDLs, oxidized LDLs, foam cells, oxidized LDL-derived chemoattractant and macrophage-derived chemoattractant, the density of macrophages, smooth muscle cells (SMCs), and extracellular matrix (ECM). The positive invariant set is found and local stability is established. Oscillatory behavior of the model solutions is also investigated. Numerical solutions show various dynamic behaviors that can occur under suitable conditions on the system parameters.http://link.springer.com/article/10.1186/s13662-017-1252-9atherosclerosisatherosclerotic plaque growthsystem stabilityHopf bifurcation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wanwarat Anlamlert Yongwimon Lenbury Jonathan Bell |
spellingShingle |
Wanwarat Anlamlert Yongwimon Lenbury Jonathan Bell Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior Advances in Difference Equations atherosclerosis atherosclerotic plaque growth system stability Hopf bifurcation |
author_facet |
Wanwarat Anlamlert Yongwimon Lenbury Jonathan Bell |
author_sort |
Wanwarat Anlamlert |
title |
Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
title_short |
Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
title_full |
Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
title_fullStr |
Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
title_full_unstemmed |
Modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
title_sort |
modeling fibrous cap formation in atherosclerotic plaque development: stability and oscillatory behavior |
publisher |
SpringerOpen |
series |
Advances in Difference Equations |
issn |
1687-1847 |
publishDate |
2017-07-01 |
description |
Abstract Atherosclerosis usually occurs within the large arteries. It is characterized by the inflammation of the intima, which involves dynamic interactions between the plasma molecules; namely, LDL (low density lipoproteins), monocytes or macrophages, cellular components and the extracellular matrix of the arterial wall. This process is referred to as plaque formation. If the accumulation of LDL cholesterol progresses unchecked, atherosclerotic plaques will form as a result of increased number of proliferating smooth muscle cells (SMCs) and extracellular lipid. This can thicken the artery wall and interfere further with blood flow. The growth of the plaques can become thrombotic and unstable, ending in rupture which gives rise to many life threatening illnesses, such as coronary heart disease, cardiovascular diseases, myocardial infarction, and stroke. A mathematical model of the essential chemical processes associated with atherosclerotic plaque development is analyzed, considering the concentrations of LDLs, oxidized LDLs, foam cells, oxidized LDL-derived chemoattractant and macrophage-derived chemoattractant, the density of macrophages, smooth muscle cells (SMCs), and extracellular matrix (ECM). The positive invariant set is found and local stability is established. Oscillatory behavior of the model solutions is also investigated. Numerical solutions show various dynamic behaviors that can occur under suitable conditions on the system parameters. |
topic |
atherosclerosis atherosclerotic plaque growth system stability Hopf bifurcation |
url |
http://link.springer.com/article/10.1186/s13662-017-1252-9 |
work_keys_str_mv |
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