UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development.

UTX (KDM6A) and UTY are homologous X and Y chromosome members of the Histone H3 Lysine 27 (H3K27) demethylase gene family. UTX can demethylate H3K27; however, in vitro assays suggest that human UTY has lost enzymatic activity due to sequence divergence. We produced mouse mutations in both Utx and Ut...

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Bibliographic Details
Main Authors: Karl B Shpargel, Toru Sengoku, Shigeyuki Yokoyama, Terry Magnuson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3459986?pdf=render

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