High Dosage Lithium Treatment Induces DNA Damage and p57<sup>Kip2</sup> Decrease

Lithium salt is the first-line therapeutic option for bipolar disorder and has been proposed as a potential antitumoral drug. The effects of LiCl treatment were investigated in SH-SY5Y, a human neuroblastoma cell line and an in vitro model of dopaminergic neuronal differentiation. LiCl, at the dosag...

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Bibliographic Details
Main Authors: Emanuela Stampone, Debora Bencivenga, Clementina Barone, Arianna Aulitto, Federica Verace, Fulvio Della Ragione, Adriana Borriello
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/3/1169