PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

In mammalian cells, classical non-homologous end joining (c-NHEJ) is critical for DNA double-strand break repair induced by ionizing radiation and during V(D)J recombination in developing B and T lymphocytes. Recently, PAXX was identified as a c-NHEJ core component. We report here that PAXX-deficien...

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Bibliographic Details
Main Authors: Satish K. Tadi, Carine Tellier-Lebègue, Clément Nemoz, Pascal Drevet, Stéphane Audebert, Sunetra Roy, Katheryn Meek, Jean-Baptiste Charbonnier, Mauro Modesti
Format: Article
Language:English
Published: Elsevier 2016-10-01
Series:Cell Reports
Subjects:
DNA double-strand break repair
NHEJ
V(D)J recombination
MMEJ
PAXX
XLF
XRCC4
Ku
Ku70
DNA ligase 4
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716312487

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