Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry
Tavernier et al. decipher the mechanism by which the intrinsically disordered protein Bora, phosphorylated by Cyclin-Cdk, potentiates AURKA activity towards Polo-like kinase 1. Furthermore, they demonstrate the importance of this mechanism for timely mitotic entry in Xenopus and human cells.
Bibliographic Details
| Main Authors: |
N. Tavernier,
Y. Thomas,
S. Vigneron,
P. Maisonneuve,
S. Orlicky,
P. Mader,
S. G. Regmi,
L. Van Hove,
N. M. Levinson,
G. Gasmi-Seabrook,
N. Joly,
M. Poteau,
G. Velez-Aguilera,
O. Gavet,
A. Castro,
M. Dasso,
T. Lorca,
F. Sicheri,
L. Pintard |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-21922-w
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