Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT

Infections with the pathogenic bacterium Clostridioides (C.) difficile are coming more into focus, in particular in hospitalized patients after antibiotic treatment. C. difficile produces the exotoxins TcdA and TcdB. Since some years, hypervirulent strains are described, which produce in addition th...

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Bibliographic Details
Main Authors: Michael Korbmacher, Stephan Fischer, Marc Landenberger, Panagiotis Papatheodorou, Klaus Aktories, Holger Barth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
C. difficile infection
large clostridial glucosylating toxins
binary actin ADP-ribosylating toxin
toxin inhibitor
AB-type protein toxins
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01204/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01204/full

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