IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes t...

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Bibliographic Details
Main Authors: Qingxiao Song, Xiaoning Wang, Xiwei Wu, Tae Hyuk Kang, Hanjun Qin, Dongchang Zhao, Robert R. Jenq, Marcel R. M. van den Brink, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21133-3

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