Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.

Spaceflight is associated with deregulation in the immune system. Head-down bed rest (HDBR) at -6° is believed to be the most practical model for examining multi-system responses to microgravity in humans during spaceflight. In the present study, a 45-day HDBR was performed to investigate the altera...

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Main Authors: Xi Xu, Cheng Tan, Pingping Li, Shusong Zhang, Xuewen Pang, Hongju Liu, Li Li, Xiuyuan Sun, Yu Zhang, Hounan Wu, Xiaoping Chen, Qing Ge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3797033?pdf=render
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spelling doaj-c8516ad3291e4b2fae51c6aefa784c102020-11-25T02:45:37ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7740110.1371/journal.pone.0077401Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.Xi XuCheng TanPingping LiShusong ZhangXuewen PangHongju LiuLi LiXiuyuan SunYu ZhangHounan WuXiaoping ChenQing GeSpaceflight is associated with deregulation in the immune system. Head-down bed rest (HDBR) at -6° is believed to be the most practical model for examining multi-system responses to microgravity in humans during spaceflight. In the present study, a 45-day HDBR was performed to investigate the alterations in human immune cell distributions and their functions in response to various stimuli. The effect of countermeasure, Rhodiola rosea (RR) treatment, was also examined. A significant decrease of interferon-γ (IFN-γ) and interleukin-17 (IL-17) productions by activated T cells, increase of IL-1β and IL-18 by activated B and myeloid cells were observed during HDBR. The upregulation of serum cortisol was correlated with the changes of IL-1 family cytokines. In addition, a significant increase of memory T and B cell and regulatory T cells (Treg) were also detected. The uptake of RR further decreased IFN-γ level and slowed down the upregulation of IL-1 family cytokines. These data suggest that for prolonged HDBR and spaceflight, the decreased protective T cell immunity and enhanced proinflammatory cytokines should be closely monitored. The treatment with RR may play an important role in suppressing proinflammatory cytokines but not in boosting protective T cell immunity.http://europepmc.org/articles/PMC3797033?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Xi Xu
Cheng Tan
Pingping Li
Shusong Zhang
Xuewen Pang
Hongju Liu
Li Li
Xiuyuan Sun
Yu Zhang
Hounan Wu
Xiaoping Chen
Qing Ge
spellingShingle Xi Xu
Cheng Tan
Pingping Li
Shusong Zhang
Xuewen Pang
Hongju Liu
Li Li
Xiuyuan Sun
Yu Zhang
Hounan Wu
Xiaoping Chen
Qing Ge
Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
PLoS ONE
author_facet Xi Xu
Cheng Tan
Pingping Li
Shusong Zhang
Xuewen Pang
Hongju Liu
Li Li
Xiuyuan Sun
Yu Zhang
Hounan Wu
Xiaoping Chen
Qing Ge
author_sort Xi Xu
title Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
title_short Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
title_full Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
title_fullStr Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
title_full_unstemmed Changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
title_sort changes of cytokines during a spaceflight analog--a 45-day head-down bed rest.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2013-01-01
description Spaceflight is associated with deregulation in the immune system. Head-down bed rest (HDBR) at -6° is believed to be the most practical model for examining multi-system responses to microgravity in humans during spaceflight. In the present study, a 45-day HDBR was performed to investigate the alterations in human immune cell distributions and their functions in response to various stimuli. The effect of countermeasure, Rhodiola rosea (RR) treatment, was also examined. A significant decrease of interferon-γ (IFN-γ) and interleukin-17 (IL-17) productions by activated T cells, increase of IL-1β and IL-18 by activated B and myeloid cells were observed during HDBR. The upregulation of serum cortisol was correlated with the changes of IL-1 family cytokines. In addition, a significant increase of memory T and B cell and regulatory T cells (Treg) were also detected. The uptake of RR further decreased IFN-γ level and slowed down the upregulation of IL-1 family cytokines. These data suggest that for prolonged HDBR and spaceflight, the decreased protective T cell immunity and enhanced proinflammatory cytokines should be closely monitored. The treatment with RR may play an important role in suppressing proinflammatory cytokines but not in boosting protective T cell immunity.
url http://europepmc.org/articles/PMC3797033?pdf=render
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