PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION

ABSTRACT: The main objective of this research work was to model and optimise the production of a locally-developed Infectious Coryza (IC) vaccine. The simulation work was performed using a commercially available batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analyse...

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Main Authors:	Nurul Huda Mohamed Safri, Maizirwan Mel, Dominic C.Y. Foo, Denny K.S. Ng, Irene M.L. Chew
Format:	Article
Language:	English
Published:	IIUM Press, International Islamic University Malaysia 2012-05-01
Series:	International Islamic University Malaysia Engineering Journal
Online Access:	http://journals.iium.edu.my/ejournal/index.php/iiumej/article/view/299

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spelling	doaj-c84c399978f140039bbbc4e5e77757942020-11-25T01:24:47ZengIIUM Press, International Islamic University MalaysiaInternational Islamic University Malaysia Engineering Journal1511-788X2289-78602012-05-0113110.31436/iiumej.v13i1.299PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTIONNurul Huda Mohamed SafriMaizirwan Mel0Dominic C.Y. FooDenny K.S. NgIrene M.L. ChewBiotechnology Engineering Department Kulliyah of Engineering, IIUM P.O box 10, 50728 Kuala LumpurABSTRACT: The main objective of this research work was to model and optimise the production of a locally-developed Infectious Coryza (IC) vaccine. The simulation work was performed using a commercially available batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production was set to increase by 100%. Based on the economic analysis, the selected debottlenecking scheme has an annual predicted revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years. ABSTRAK: Objektif utama dalam penyelidikan ini adalah untuk memodelkan dan mengoptimumkan hasil pembuatan vaksin tempatan Coryza berjangkit. Kerja simulasi ini dijalankan menggunakan alat simulasi Super Pro Designer v5.5. Sebanyak enam (6) skema khusus diujikaji menggunakan analisis pemprosesan dan kos kepada nisbah faedah (CBR) apabila pembuatan tahunan meningkat kepada 100%. Berdasarkan analisis ekonomi yang telah dilakukan, sesuatu skema khusus yang dipilih mempunyai keuntungan sebanyak USD 240 juta dengan margin kasar 9.13% dan pulangan atas pelaburan (ROI) sebanyak 46.12%. Selain itu juga, tempoh pembayaran balik bagi skema yang dipilih dianggarkan dalam tempoh tiga(3) tahun. KEYWORDS: process simulation; modelling; debottlenecking; optimisation http://journals.iium.edu.my/ejournal/index.php/iiumej/article/view/299
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nurul Huda Mohamed Safri Maizirwan Mel Dominic C.Y. Foo Denny K.S. Ng Irene M.L. Chew
spellingShingle	Nurul Huda Mohamed Safri Maizirwan Mel Dominic C.Y. Foo Denny K.S. Ng Irene M.L. Chew PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION International Islamic University Malaysia Engineering Journal
author_facet	Nurul Huda Mohamed Safri Maizirwan Mel Dominic C.Y. Foo Denny K.S. Ng Irene M.L. Chew
author_sort	Nurul Huda Mohamed Safri
title	PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION
title_short	PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION
title_full	PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION
title_fullStr	PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION
title_full_unstemmed	PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION
title_sort	process modelling and debottlenecking study of a vaccine production
publisher	IIUM Press, International Islamic University Malaysia
series	International Islamic University Malaysia Engineering Journal
issn	1511-788X 2289-7860
publishDate	2012-05-01
description	ABSTRACT: The main objective of this research work was to model and optimise the production of a locally-developed Infectious Coryza (IC) vaccine. The simulation work was performed using a commercially available batch process simulator SuperPro Designer v5.5. Six debottlenecking schemes were analysed using throughput analysis and cost to benefit ratio (CBR) when the annual production was set to increase by 100%. Based on the economic analysis, the selected debottlenecking scheme has an annual predicted revenue of USD 240 million, with a gross margin of 9.13% and a return on investment (ROI) of 46.12%. In addition, the payback period of the selected scheme is estimated to be within three years. ABSTRAK: Objektif utama dalam penyelidikan ini adalah untuk memodelkan dan mengoptimumkan hasil pembuatan vaksin tempatan Coryza berjangkit. Kerja simulasi ini dijalankan menggunakan alat simulasi Super Pro Designer v5.5. Sebanyak enam (6) skema khusus diujikaji menggunakan analisis pemprosesan dan kos kepada nisbah faedah (CBR) apabila pembuatan tahunan meningkat kepada 100%. Berdasarkan analisis ekonomi yang telah dilakukan, sesuatu skema khusus yang dipilih mempunyai keuntungan sebanyak USD 240 juta dengan margin kasar 9.13% dan pulangan atas pelaburan (ROI) sebanyak 46.12%. Selain itu juga, tempoh pembayaran balik bagi skema yang dipilih dianggarkan dalam tempoh tiga(3) tahun. KEYWORDS: process simulation; modelling; debottlenecking; optimisation
url	http://journals.iium.edu.my/ejournal/index.php/iiumej/article/view/299
work_keys_str_mv	AT nurulhudamohamedsafri processmodellinganddebottleneckingstudyofavaccineproduction AT maizirwanmel processmodellinganddebottleneckingstudyofavaccineproduction AT dominiccyfoo processmodellinganddebottleneckingstudyofavaccineproduction AT dennyksng processmodellinganddebottleneckingstudyofavaccineproduction AT irenemlchew processmodellinganddebottleneckingstudyofavaccineproduction
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PROCESS MODELLING AND DEBOTTLENECKING STUDY OF A VACCINE PRODUCTION

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