| Summary: | ABSTRACT Background: Systematization of characteristics and morphological changes in the retina, and understanding its role in occlusive diseases involving retinal vessels can contribute to research on the dynamic of the pathological process and to improved understanding of disease treatment. Objective: To research the basic morphometric and structural indicators of the macular region of the retina in patients with central retinal vein occlusion (CRVO). Settings and Design: Ufa Eye Research Institute, retrospective case series. Methods: The basic morphometric and structural indices of the macular region of the retina in 15 patients with CRVO were studied using the optical coherence tomography. Patients with CRVO (15 eyes) were included in Group I (study), and 10 patients with no retinal pathology (10 eyes) were included in Group II (control). Statistical analysis used: For the statistical analysis, the Statistica 6.1 program was used with a parametric method, the Student's test.To consider the probability of statistically significant differences, values beginning with up to p<0.05 were accepted. Results: In Group II, we determined the correct profile of the macula with fovea centralis and a range of retinal thickness from 221.4 ± 10.97 to 355.2 ± 12.17 µm, with an average value of - 299.01 ± 7.56 µm. In Group I mean retinal thickness at all points of the study area ranged from 247.86 ± 39.06 to 494.07 ± 40.22 µm with a gradual thickening of the periphery to the center, reaching a maximum at a distance of 893 µm from the center of the fovea. The average thickness of the retina as a result of edema increased by a multiple of 1.3 and amounted to - 386.97 ± 16.26 µm. Conclusions: The study indicated that the edema is the main morphological substrate, promoting structural changes in the central retina in retinal vein occlusion, and is cystic in nature. Increase in total retinal thickness (up to 386.97 ± 16.26 µm) in this pathology is largely due to the structural changes in zones, covering the îuter plexiform layer - the inner nuclear layer and the nerve fiber layer with the inner limiting membrane. Meanwhile a significant increase in the thickness of the outer plexiform with the inner nuclear layers (up to 94.94 ± 5.08 µm) and nerve fiber layers (up to 54.6 ± 3.26µm) was observed.
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