A Computational Study of the Effects of Tachycardia-Induced Remodeling on Calcium Wave Propagation in Rabbit Atrial Myocytes

In atrial cardiomyocytes without a well-developed T-tubule system, calcium diffuses from the periphery toward the center creating a centripetal wave pattern. During atrial fibrillation, rapid activation of atrial myocytes induces complex remodeling in diffusion properties that result in failure of c...

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Bibliographic Details
Main Authors: Márcia R. Vagos, Hermenegild Arevalo, Jordi Heijman, Ulrich Schotten, Joakim Sundnes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.651428/full