The Association of Demographic and Clinical Factors with the Frequency of Restenosis in Patients Undergoing Angioplasty Using Negative Binomial Regression

• Main Authors: J Nasseryan, E Hajizadeh, A Rasekhi, H Ahangar
• Format: Article
• Language: fas
• Published: Tehran University of Medical Sciences 2016-08-01
• Series: مجله اپیدمیولوژی ایران
• Subjects: angioplasty; restenosis; over dispersion; negative binomial regression
• Online Access: http://irje.tums.ac.ir/article-1-5512-en.html

Background and Objectives: One of the main concerns of heart specialists is the occurrence of restenosis after coronary angioplasty which can lead to coronary artery bypass graft, myocardial infarction, and death. The present study was conducted to investigate the factors affecting the frequency of restenosis during four years in patients of Zanjan.  Methods: In the present retrospective cohort study, all the patients who underwent angioplasty in Ayatollah Musavi Hospital of Zanjan from April of 2009 to June of 2011 were examined in terms of the frequency of restenosis. According to the patients’ medical records, all the demographic and clinical data of the patients were collected. Since the dependent variable was count in nature and the data were over-dispersed, negative binomial regression was used for modeling. Results: The incidence of at least one restenosis during four years after angioplasty was calculated to be 43%. According to the negative binomial regression model, the ratio of restenosis in patients suffering from diabetes, unstable angina, chronic kidney disease, and myocardial infarction was 32%, 44%, 66%, and 30% more than other patients, respectively (P<0.05). Conclusion: In the present study, the effective factors of restenosis were recognized as diabetes, unstable angina, chronic kidney disease, and history of myocardial infarction; hence, assessment and periodic follow-up of these patients are strongly recommended.