| Summary: | Although the biological mechanisms underlying the beneficial effects of vitamin B<sub>6</sub> on cardiovascular disease (CVD) have been reported on, epidemiological studies have yielded controversial results, and data on the Korean population are limited. This study examined the association between dietary vitamin B<sub>6</sub> intake and CVD incidence in Koreans. A total of 9142 participants of the Korean Genome and Epidemiology Study, aged 40−69 years, who did not have CVD or cancer at the baseline were included in the analysis. Dietary data were assessed using a validated semi-quantitative food frequency questionnaire. CVD incidence was assessed using biennial questionnaires and confirmed through repeated personal interviews. Multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard regression models. After multivariate adjustment, a higher vitamin B<sub>6</sub> intake was significantly associated with a decreased CVD risk in men (HR: 0.44; 95% CI: 0.25−0.78); no such association was observed in women. Dose-response analysis confirmed the presence of inverse linearity between vitamin B<sub>6</sub> intake and CVD incidence in men (<i>p</i> for nonlinearity = 0.3). A higher dietary intake level of vitamin B<sub>6</sub> was associated with a reduced CVD risk in Korean men. These observations require further verification in other populations.
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