Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction.

Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction.

Heart failure with a preserved ejection fraction (HFpEF) is associated with multiple comorbidities, such as old age, hypertension, type 2 diabetes and obesity and is more prevalent in females. Although the male obese ZSF1 rat has been proposed as a suitable model to study the development of diastoli...

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Main Authors: Isabel T N Nguyen, Maarten M Brandt, Jens van de Wouw, Ruben W A van Drie, Marian Wesseling, Maarten J Cramer, Saskia C A de Jager, Daphne Merkus, Dirk J Duncker, Caroline Cheng, Jaap A Joles, Marianne C Verhaar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0232399

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https://doi.org/10.1371/journal.pone.0232399

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