MOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice
Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and that p...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-07-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124714004380 |
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by Arun Gupta, Clayton R. Hunt, Muralidhar L. Hegde, Sharmistha Chakraborty, Durga Udayakumar, Nobuo Horikoshi, Mayank Singh, Deepti B. Ramnarain, Walter N. Hittelman, Sarita Namjoshi, Aroumougame Asaithamby, Tapas K. Hazra, Thomas Ludwig, Raj K. Pandita, Jessica K. Tyler, Tej K. Pandita
Published 2014-07-01
Get full textPublished 2014-07-01
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