Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog

Quantitative analysis of the impact of a human pathogenic mutation on the CCT5 chaperonin subunit using a proxy archaeal ortholog

The human chaperonin complex is a ~ 1 MDa nanomachine composed of two octameric rings formed from eight similar but non-identical subunits called CCT. Here, we are elucidating the mechanism of a heritable CCT5 subunit mutation that causes profound neuropathy in humans. In previous work, we introduce...

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Bibliographic Details
Main Authors: Dario Spigolon, D. Travis Gallagher, Adrian Velazquez-Campoy, Donatella Bulone, Jatin Narang, Pier Luigi San Biagio, Francesco Cappello, Alberto J.L. Macario, Everly Conway de Macario, Frank T. Robb
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Chaperonopathies
CCT5
Pyrococcus furiosus
Chaperonin
Protein calorimetry
Neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580817301176

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