The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context

The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context

Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic intervention efficacy is extremely difficult, presenti...

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Main Authors: Ken Kijima, Kensuke Kubota, Masamitsu Hara, Kazu Kobayakawa, Kazuya Yokota, Takeyuki Saito, Shingo Yoshizaki, Takeshi Maeda, Daijiro Konno, Yoshihiro Matsumoto, Yasuharu Nakashima, Seiji Okada
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419301434
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spelling doaj-c82fe87caef3465380847ea80e32e5c62020-11-25T01:58:42ZengElsevierEBioMedicine2352-39642019-03-0141659669The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in contextKen Kijima0Kensuke Kubota1Masamitsu Hara2Kazu Kobayakawa3Kazuya Yokota4Takeyuki Saito5Shingo Yoshizaki6Takeshi Maeda7Daijiro Konno8Yoshihiro Matsumoto9Yasuharu Nakashima10Seiji Okada11Department of Pathophysiology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Spinal Injuries Center, Iizuka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pathophysiology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Spinal Injuries Center, Iizuka, JapanDepartment of Pathophysiology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Pathophysiology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; Corresponding author at: Department of Pathophysiology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic intervention efficacy is extremely difficult, presenting major obstacles to the development of acute SCI treatment. We herein report a novel method for accurately predicting the functional prognosis using the acute-phase serum zinc concentration after SCI. Methods: We produced experimental animal SCI models with different prognoses and examined the relationship among the SCI severity, functional outcome, and acute-phase serum zinc concentration. We also examined whether we could predict the functional prognosis by evaluating the serum zinc concentration within 72 h after SCI in a human prospective study. Findings: In a mouse model, the acute serum zinc concentrations decreased in proportion to SCI severity and the serum zinc concentrations at 12 h after SCI accurately predicted the functional prognosis. We clarified the mechanism underlying this serum zinc proportional decrease, showing that activated monocytes took up zinc from blood-serum and then infiltrated the lesion area in a severity-dependent manner. A non-linear regression analysis of 38 SCI patients showed that the serum zinc concentrations in the acute-phase accurately predicted the long-term functional outcome (R2 = 0·84) more accurately than any other previously reported acute-phase biomarkers. Interpretation: The acute-phase serum zinc concentration could be a useful biomarker for predicting the functional prognosis. This simple method will allow for more objective clinical trials and the development of patient-tailored treatment for SCI. Keywords: Spinal cord injury, Functional outcome, Biomarker, Serum zinc concentrationhttp://www.sciencedirect.com/science/article/pii/S2352396419301434
collection DOAJ
language English
format Article
sources DOAJ
author Ken Kijima
Kensuke Kubota
Masamitsu Hara
Kazu Kobayakawa
Kazuya Yokota
Takeyuki Saito
Shingo Yoshizaki
Takeshi Maeda
Daijiro Konno
Yoshihiro Matsumoto
Yasuharu Nakashima
Seiji Okada
spellingShingle Ken Kijima
Kensuke Kubota
Masamitsu Hara
Kazu Kobayakawa
Kazuya Yokota
Takeyuki Saito
Shingo Yoshizaki
Takeshi Maeda
Daijiro Konno
Yoshihiro Matsumoto
Yasuharu Nakashima
Seiji Okada
The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
EBioMedicine
author_facet Ken Kijima
Kensuke Kubota
Masamitsu Hara
Kazu Kobayakawa
Kazuya Yokota
Takeyuki Saito
Shingo Yoshizaki
Takeshi Maeda
Daijiro Konno
Yoshihiro Matsumoto
Yasuharu Nakashima
Seiji Okada
author_sort Ken Kijima
title The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
title_short The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
title_full The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
title_fullStr The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
title_full_unstemmed The acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryResearch in context
title_sort acute phase serum zinc concentration is a reliable biomarker for predicting the functional outcome after spinal cord injuryresearch in context
publisher Elsevier
series EBioMedicine
issn 2352-3964
publishDate 2019-03-01
description Background: Spinal cord injury (SCI) is a devastating disorder for which the accurate prediction of the functional prognosis is urgently needed. Due to the lack of reliable prediction methods, the acute evaluation of SCI severity and therapeutic intervention efficacy is extremely difficult, presenting major obstacles to the development of acute SCI treatment. We herein report a novel method for accurately predicting the functional prognosis using the acute-phase serum zinc concentration after SCI. Methods: We produced experimental animal SCI models with different prognoses and examined the relationship among the SCI severity, functional outcome, and acute-phase serum zinc concentration. We also examined whether we could predict the functional prognosis by evaluating the serum zinc concentration within 72 h after SCI in a human prospective study. Findings: In a mouse model, the acute serum zinc concentrations decreased in proportion to SCI severity and the serum zinc concentrations at 12 h after SCI accurately predicted the functional prognosis. We clarified the mechanism underlying this serum zinc proportional decrease, showing that activated monocytes took up zinc from blood-serum and then infiltrated the lesion area in a severity-dependent manner. A non-linear regression analysis of 38 SCI patients showed that the serum zinc concentrations in the acute-phase accurately predicted the long-term functional outcome (R2 = 0·84) more accurately than any other previously reported acute-phase biomarkers. Interpretation: The acute-phase serum zinc concentration could be a useful biomarker for predicting the functional prognosis. This simple method will allow for more objective clinical trials and the development of patient-tailored treatment for SCI. Keywords: Spinal cord injury, Functional outcome, Biomarker, Serum zinc concentration
url http://www.sciencedirect.com/science/article/pii/S2352396419301434
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