KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report

KRAS and PIK3CA bi-mutations predict a poor prognosis in colorectal cancer patients: A single-site report

Study rationale: The coexistence of KRAS and PIK3CA mutations in cells implies potential synergistic hyperactivation of the Ras/MAPK and PI3K/Akt oncogenic pathways. Therefore, it is desirable to investigate the concomitant mutations of KRAS and PIK3CA in colorectal cancer (CRC) samples and whether...

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Bibliographic Details
Main Authors:	Qianxin Luo, Dianke Chen, Xinjuan Fan, Xinhui Fu, Tenghui Ma, Daici Chen
Format:	Article
Language:	English
Published:	Elsevier 2020-12-01
Series:	Translational Oncology
Online Access:	http://www.sciencedirect.com/science/article/pii/S1936523320303661

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