Hyperinsulinemia is associated with increased soluble insulin receptors release from hepatocytes

Hyperinsulinemia is associated with increased soluble insulin receptors release from hepatocytes

It has been generally assumed that insulin circulates freely in blood. However it can also interact with plasma proteins. Insulin receptors are located in the membrane of target cells and consist of an alpha and beta subunits with a tyrosine kinase cytoplasmic domain. The ectodomain, called soluble...

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Bibliographic Details
Main Authors: Marcia eHiriart, Carmen eSanchez-Soto, Carlos Manlio eDiaz-Garcia, Diana T eCastanares, Morena eAvitia-Cao, Myrian eVelasco, Jaime eMas-Oliva, Marina eMacias, Clicerio eGonzalez-Villalpando, Blanca eDelgado-Coello, Marcela eSosa-Garrocho, Roman eVidaltamayo, Deyanira eFuentes-Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Endocrinology
Subjects:
Hyperinsulinism
Insulin Resistance
metabolic syndrome
Protease
Diabetes mellitus type 2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00095/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00095/full

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