The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

The long non-coding RNA Kcnq1ot1 controls maternal p57 expression in muscle cells by promoting H3K27me3 accumulation to an intragenic MyoD-binding region

Abstract Background The cell-cycle inhibitor p57kip2 plays a critical role in mammalian development by coordinating cell proliferation and differentiation in many cell types. p57kip2 expression is finely regulated by several epigenetic mechanisms, including paternal imprinting. Kcnq1ot1, a long non-...

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Bibliographic Details
Main Authors: Oriella Andresini, Marianna Nicoletta Rossi, Francesca Matteini, Stefano Petrai, Tiziana Santini, Rossella Maione
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Epigenetics & Chromatin
Subjects:
p57kip2/Cdkn1c
Kcnq1ot1
Muscle differentiation
MyoD
H3K27me3
Imprinting
Online Access:http://link.springer.com/article/10.1186/s13072-019-0253-1

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