Co-culture of hWJMSCs and pACs in double biomimetic ACECM oriented scaffold enhances mechanical properties and accelerates articular cartilage regeneration in a caprine model

Co-culture of hWJMSCs and pACs in double biomimetic ACECM oriented scaffold enhances mechanical properties and accelerates articular cartilage regeneration in a caprine model

Abstract Background The dedifferentiation of chondrocytes and the unstable chondrogenic differentiation status of pluripotent mesenchymal stem cells (MSCs) are immense issues in cell-based articular cartilage repair and regenerative strategies. Here, to improve the cartilage characteristics of seed...

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Bibliographic Details
Main Authors: Yu Zhang, Chunxiang Hao, Weimin Guo, Xiaoyu Peng, Mingjie Wang, Zhen Yang, Xu Li, Xueliang Zhang, Mingxue Chen, Xiang Sui, Jiang Peng, Shibi Lu, Shuyun Liu, Quanyi Guo, Qing Jiang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Stem Cell Research & Therapy
Subjects:
Acellular cartilage extracellular matrix-oriented scaffold
Human umbilical cord Wharton’s jelly-derived mesenchymal stem cell
Primary cartilage cell
Co-culture system
Online Access:http://link.springer.com/article/10.1186/s13287-020-01670-2

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