Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans
Data from clinical and cross-sectional studies suggest that inflammation contributes to psychomotor slowing and attentional deficits found in depressive disorder. However, experimental evidence is still lacking. The aim of this study was to clarify the effect of inflammation on psychomotor slowing u...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Brain, Behavior, & Immunity - Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666354620300958 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Analena Handke John Axelsson Sven Benson Karoline Boy Vera Weskamp Till Hasenberg Miriam Remy Johannes Hebebrand Manuel Föcker Alexandra Brinkhoff Meike Unteroberdörster Harald Engler Manfred Schedlowski Julie Lasselin |
| spellingShingle |
Analena Handke John Axelsson Sven Benson Karoline Boy Vera Weskamp Till Hasenberg Miriam Remy Johannes Hebebrand Manuel Föcker Alexandra Brinkhoff Meike Unteroberdörster Harald Engler Manfred Schedlowski Julie Lasselin Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans Brain, Behavior, & Immunity - Health Inflammation Psychomotor slowing Reaction time Go/no-go Sickness Lipopolysaccharide |
| author_facet |
Analena Handke John Axelsson Sven Benson Karoline Boy Vera Weskamp Till Hasenberg Miriam Remy Johannes Hebebrand Manuel Föcker Alexandra Brinkhoff Meike Unteroberdörster Harald Engler Manfred Schedlowski Julie Lasselin |
| author_sort |
Analena Handke |
| title |
Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans |
| title_short |
Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans |
| title_full |
Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans |
| title_fullStr |
Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans |
| title_full_unstemmed |
Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humans |
| title_sort |
acute inflammation and psychomotor slowing: experimental assessment using lipopolysaccharide administration in healthy humans |
| publisher |
Elsevier |
| series |
Brain, Behavior, & Immunity - Health |
| issn |
2666-3546 |
| publishDate |
2020-10-01 |
| description |
Data from clinical and cross-sectional studies suggest that inflammation contributes to psychomotor slowing and attentional deficits found in depressive disorder. However, experimental evidence is still lacking. The aim of this study was to clarify the effect of inflammation on psychomotor slowing using an experimental and acute model of inflammation, in which twenty-two healthy volunteers received an intravenous injection of lipopolysaccharide (LPS, dose: 0.8 ng/kg body weight) and of placebo, in a randomized order following a double-blind within-subject crossover design. A reaction time test and a go/no-go test were conducted 3 h after the LPS/placebo injection and interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were assessed. No effect of experimental inflammation on reaction times or errors for either test was found. However, inflammation was related to worse self-rated performance and lower effort put in the tasks. Exploratory analyses indicated that reaction time fluctuated more over time during acute inflammation. These data indicate that acute inflammation has only modest effects on psychomotor speed and attention in healthy subjects objectively, but alters the subjective evaluation of test performance. Increased variability in reaction time might be the first objective sign of altered psychomotor ability and would merit further investigation. |
| topic |
Inflammation Psychomotor slowing Reaction time Go/no-go Sickness Lipopolysaccharide |
| url |
http://www.sciencedirect.com/science/article/pii/S2666354620300958 |
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doaj-c810d1c8405249bdb62170fbe15d0eff2021-06-10T04:57:47ZengElsevierBrain, Behavior, & Immunity - Health2666-35462020-10-018100130Acute inflammation and psychomotor slowing: Experimental assessment using lipopolysaccharide administration in healthy humansAnalena Handke0John Axelsson1Sven Benson2Karoline Boy3Vera Weskamp4Till Hasenberg5Miriam Remy6Johannes Hebebrand7Manuel Föcker8Alexandra Brinkhoff9Meike Unteroberdörster10Harald Engler11Manfred Schedlowski12Julie Lasselin13Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyStress Research Institute, Stockholm University, Stockholm, Sweden; Division for Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyHelios Adipositas Zentrum West, Helios St. Elisabeth Klinik Oberhausen, Witten/Herdecke University, Oberhausen, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, GermanyDepartment of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Germany; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Muenster, Muenster, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, Germany; Department of Nephrology, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, Germany; Department of Neurosurgery, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, GermanyInstitute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, Germany; Stress Research Institute, Stockholm University, Stockholm, Sweden; Division for Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Corresponding author. Stress Research Institute, Stockholm University, 106 91, Stockholm, Sweden.Data from clinical and cross-sectional studies suggest that inflammation contributes to psychomotor slowing and attentional deficits found in depressive disorder. However, experimental evidence is still lacking. The aim of this study was to clarify the effect of inflammation on psychomotor slowing using an experimental and acute model of inflammation, in which twenty-two healthy volunteers received an intravenous injection of lipopolysaccharide (LPS, dose: 0.8 ng/kg body weight) and of placebo, in a randomized order following a double-blind within-subject crossover design. A reaction time test and a go/no-go test were conducted 3 h after the LPS/placebo injection and interleukin (IL)-6 and tumor necrosis factor (TNF)-α concentrations were assessed. No effect of experimental inflammation on reaction times or errors for either test was found. However, inflammation was related to worse self-rated performance and lower effort put in the tasks. Exploratory analyses indicated that reaction time fluctuated more over time during acute inflammation. These data indicate that acute inflammation has only modest effects on psychomotor speed and attention in healthy subjects objectively, but alters the subjective evaluation of test performance. Increased variability in reaction time might be the first objective sign of altered psychomotor ability and would merit further investigation.http://www.sciencedirect.com/science/article/pii/S2666354620300958InflammationPsychomotor slowingReaction timeGo/no-goSicknessLipopolysaccharide |