Relación entre la enzima convertidora de angiotensina, polimorfismo I/D, y obstrucción coronaria en una población del Quindío, Colombia

• Main Authors: Patricia Landázuri, Hugo Castaño, Nelsy Loango, Andrea Cardona-Barreto, Alejandra María Giraldo
• Format: Article
• Language: English
• Published: Pontificia Universidad Javeriana 2011-12-01
• Series: Universitas Scientiarum
• Subjects: angiotensin-converting enzyme; coronary obstruction; ID polymorphism; angiotensin.
• Online Access: http://revistas.javeriana.edu.co/index.php/scientarium/article/view/1792/1152

Relationship between angiotensin-converting enzyme, I/D polymorphism, and coronary obstruction in a population of Quindío,Colombia. Angiotensin-converting enzyme (ACE) activity in serum and insertion/deletion (I/D) polymorphism have been associated tocardiovascular disease in several studies. Objective. To find a relationship between ACE activity and I/D polymorphism in the enzymegene in patients with coronary obstruction revealed by angiography. Materials and methods. Sample comprised patients attending ahemodynamics center in Quindío in need of a coronary angiography. ACE activity was measured by spectrophotometry and the I/Dgenotype determined by polymerase chain reaction. Results. 542 patients were divided into two groups: individuals with coronaryobstruction higher than or equal to 50% (OC≥50) and individuals with coronary obstruction less than 50% (CO<50%). Serum ACEactivity in the global population was higher in individuals with DD polymorphism, followed by ID and II with significant differences.A similar pattern was shown in both study groups but without significant differences, although enzyme activity was always higher inindividuals with OC≥50% compared with patients with OC<50%. ID genotype was the most frequent in both groups. No differenceswere found in allele and genotype frequencies in the study groups. Conclusions. Significant differences in ACE activity were foundaccording to genotype. Our study did not find any relationship between ACE activity, I/D polymorphisms and coronary obstruction.