Hypoxia Induces Dysregulation of Lipid Metabolism in HepG2 Cells via Activation of HIF-2α

Hypoxia Induces Dysregulation of Lipid Metabolism in HepG2 Cells via Activation of HIF-2α

Background: Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. The current study examined the effect of HIF-2α, an oxygen-sensitive heterodimeric transcription factor, on hypoxia-induced dysregulation of lip...

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Bibliographic Details
Main Authors: Risheng Cao, Xiaodan Zhao, Shuo Li, Haiyun Zhou, Weixu Chen, Lihua Ren, Xiqiao Zhou, Hongjie Zhang, Ruihua Shi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
HIF-2α
HepG2
Fatty acid metabolism
Cholesterol metabolism
Online Access:http://www.karger.com/Article/FullText/366348

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