• Main Authors: Michel Rodrigues Moreira, Munick Paula Guimarães, Aurélia Aparecida de Araújo Rodrigues, Paulo Pinto Gontijo Filho
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2013-01-01
• Series: Revista da Sociedade Brasileira de Medicina Tropical
• Subjects: Antibiotic consumption; Intensive care unit; Ventilator-associated pneumonia; Antimicrobial resistance
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000100039

<sec><title>INTRODUCTION</title>: Antimicrobial resistance is an increasing threat in hospitalized patients, and inappropriate empirical antimicrobial therapy is known to adversely affect outcomes in ventilator-associated pneumonia (VAP). The aim of this study was to evaluate antimicrobial usage, incidence, etiology, and antimicrobial resistance trends for prominent nosocomial pathogens causing ventilator-associated pneumonia in a clinical-surgical intensive care unit (ICU). </sec><sec><title>METHODS</title>: Gram-negative bacilli and Staphylococcus aureus causing VAP, as well as their antimicrobial resistance patterns and data on consumption (defined daily dose [DDD] per 1,000 patient days) of glycopeptides, extended-spectrum cephalosporins, and carbapenems in the unit were evaluated in two different periods (A and B). </sec><sec><title>RESULTS:</title> Antimicrobial use was high, mainly of broad-spectrum cephalosporins, with a significant increase in the consumption of glycopeptides (p < 0.0001) and carbapenems (p < 0.007) in period B. For Acinetobacter baumannii and members of the Enterobacteriaceae family, 5.27- and 3.06-fold increases in VAPs, respectively, were noted, and a significant increase in resistance rates was found for imipenem-resistant A. baumannii (p = 0.003) and third-generation cephalosporins-resistant Enterobacteriaceae (p = 0.01) isolates in this same period. </sec><sec><title>CONCLUSIONS:</title> Our results suggest that there is a link between antibiotics usage at institutional levels and resistant bacteria. The use of carbapenems was related to the high rate of resistance in A. baumannii and therefore a high consumption of imipenem/meropenem could play a major role in selective pressure exerted by antibiotics in A. baumannii strains.</sec>