Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity.

Heterologous SUMO-2/3-ubiquitin chains optimize IκBα degradation and NF-κB activity.

The NF-κB pathway is regulated by SUMOylation at least at three levels: the inhibitory molecule IκBα, the IKK subunit γ/NEMO and the p52 precursor p100. Here we investigate the role of SUMO-2/3 in the degradation of IκBα and activation of NF-κB mediated by TNFα. We found that under conditions of def...

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Bibliographic Details
Main Authors: Fabienne Aillet, Fernando Lopitz-Otsoa, Isabel Egaña, Roland Hjerpe, Paul Fraser, Ron T Hay, Manuel S Rodriguez, Valérie Lang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3527444?pdf=render

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