Design and synthesis of novel pyrazol-3ylthiazoles
Biheterocyclic compounds in recent years have gained a significant importance in medicinal chemistry. In this paper the synthesis of novel pyrazol-3ylthiazoles through Vilsmeier–Haack reaction using 2-amino thiazoles as precursors is described. Synthesis of twelve new derivatives was accomplished wi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535214002172 |
| Summary: | Biheterocyclic compounds in recent years have gained a significant importance in medicinal chemistry. In this paper the synthesis of novel pyrazol-3ylthiazoles through Vilsmeier–Haack reaction using 2-amino thiazoles as precursors is described. Synthesis of twelve new derivatives was accomplished with moderate yield (70–76%). Structures of all the newly synthesized compounds were characterized by spectral (1H NMR, 13C NMR, IR, LC–MS) and elemental analyses. Keywords: Pyrazole, 1,3-Thiazole, 2-Aminothiazole, Vilsmeier reaction |
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| ISSN: | 1878-5352 |