A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

A Polyethylenimine-Linoleic Acid Conjugate for Antisense Oligonucleotide Delivery

A novel antisense oligonucleotide (ASO) carrier, polyethylenimine conjugated to linoleic acid (PEI-LA), was synthesized and evaluated for delivery of LOR-2501 to tumor cells. LOR-2501 is an ASO targeting ribonucleotide reductase R1 subunit (RRM1). In this study, PEI-LA was synthesized by reacting PE...

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Bibliographic Details
Main Authors:	Jing Xie, Lesheng Teng, Zhaogang Yang, Chenguang Zhou, Yang Liu, Bryant C. Yung, Robert J. Lee
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2013/710502

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