Successful management of presumed <i> Candida</i> endogenous endophthalmitis with oral voriconazole

• Main Authors: Biju Raju, Sushil Daniel, Georgy Nainan
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2009-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: <i>Candida</i> endophthalmitis; endophthalmitis; endogenous endophthalmitis; fungal endophthalmitis; voriconazole
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2009;volume=57;issue=4;spage=306;epage=308;aulast=Biju

Endogenous fungal endophthalmitis is most commonly caused by <i> Candida </i> species and usually occurs in patients with chronic diseases such as diabetes mellitus and renal insufficiency. Voriconazole, a broad-spectrum triazole antifungal agent, attains therapeutically significant concentrations in the vitreous cavity after systemic administration. We report, the successful management of presumed endogenous <i> Candida</i> endophthalmitis in a patient with multiple diseases and unstable systemic status with oral voriconazole. Though fungal endophthalmitis has been successfully treated with a combination of intravenous and intravitreal voriconazole, to the best of our knowledge this is the first report in ophthalmic literature (Medline Search) on the treatment of fungal endophthalmitis with only the oral route of administration of voriconazole.