| Summary: | Essential oils (EOs) have been recognized as materials of interest for dermatological applications, although some doubts remain regarding their safety and efficacy. We studied the action mechanisms of EOs from lavender and sage in human skin. Extracted EOs were incorporated (at 5% and 10%) in almond oil as a vehicle. Eleven healthy volunteers were selected and the prepared oils were tested on both forearms. All procedures respected the principles of good clinical practice. Effects were followed through high resolution sonography (HRS), epidermal water dynamics, and biomechanics. All variables were measured before and 30 min after application. Nonparametric statistical comparisons were applied (<i>p</i> < 0.05). HRS revealed a more echogenic epidermis, with a significant echogenicity decrease in the dermis (higher water retention) for all formulations. Significant TEWL decrease and an increase in superficial and deep epidermal hydration were also observed. These results indicate that EOs penetrate only into the most superficial layers of the skin, which is important for their safety profile. Furthermore, this “filmogenic” mechanism improving the epidermal water balance seems to connect directly with the observed biomechanical enhancement. These results confirm the clinical relevance of these compounds, in particular to restore the epidermal water content and prevent xerosis and other related disorders in sensitive (atopic, elderly) patients.
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